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Diagnostic Challenges of Celiac Disease



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Genetic Tests-Big Limitation5

Slide 19

June 2010

So that brings to our notice the big limitation of this type of genetic testing. First of all, having the HLA type does not equal the disease. Most people with the at-risk types will not have celiac disease. Two-thirds of family members of people with celiac disease will carry the at-risk types, but most of these don’t get the disease. Another category of individuals who are at risk for celiac disease are type 1 diabetics, also known as juvenile onset diabetes. And fully 50% of those individuals carry the same HLA type as risk for celiac disease, but only 6% of them will get celiac disease.

Genetic Tests-Big Limitation5

 


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