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QuantiFERON-TB Gold In-Tube

Applications and Keys to Accurate Performance


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QuantiFERON-TB Gold In-Tube Applications, cont.

Slide 16

November 2009

It does raise the question, “Does QuantiFERON In-Tube demonstrate a lower sensitivity compared to the tuberculin skin test?” 

This question is challenging to answer, because it’s difficult to accurately estimate the sensitivity of these assays due to the absence of a gold standard method to arbitrate discordant results.

However, the CDC has stated that “A greater rate of positive results with the skin test than with QuantiFERON has been observed in persons WITH and WITHOUT recognized risks of Mycobacterium tuberculosis infection.”  So I think this issue remains somewhat controversial.

Applications, cont.


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