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QuantiFERON-TB Gold In-Tube

Applications and Keys to Accurate Performance



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QuantiFERON-TB Gold In-Tube Applications

Slide 11

November 2009

Now I’d like to turn our attention to the applications of QuantiFERON and also discuss the assay’s key performance characteristics. I think one of the major questions that clinicians and laboratorians are asking is “Can interferon gamma release assays, such as QuantiFERON, be used in place of the tuberculin skin test?”  In 2005, a panel of experts in the field of TB diagnostics, including members of the CDC, drafted a guidance document on the use and interpretation of QuantiFERON. In this document, the group concluded that QuantiFERON can be used in all circumstances in which the tuberculin skin test is used, including the following scenarios; contact investigations, evaluation of recent immigrants with a history of BCG vaccination, TB screening of health care workers, and serial evaluation for the diagnosis of TB infection.

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