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QuantiFERON-TB Gold In-Tube

Applications and Keys to Accurate Performance


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QuantiFERON-TB Gold In-Tube Limitations

Slide 10

November 2009

Although there are significant advantages of QuantiFERON over conventional testing, there are also several limitations to this method. Despite QuantiFERON showing enhanced specificity, studies have shown that this method may still demonstrate cross-reactivity with some nontuberculous mycobacterial infections, including those caused by Mycobacterium kansasii, Mycobacterium szulgai and Mycobacterium marinum. A second limitation is the paucity of data for QuantiFERON in certain patient populations, including young children, immunocompromised patients, and pregnant women. Due to the lack of studies with these groups of patients, the interpretation of QuantiFERON results can be difficult, and future studies are needed.



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