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QuantiFERON-TB Gold In-Tube

Applications and Keys to Accurate Performance


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Slide 1

November 2009

Welcome to Mayo Medical Laboratories' Hot Topics. These presentations provide short discussion of current topics and may be helpful to you in your practice.

Our presenter for this program is Dr. Matthew Binnicker, Assistant Professor of Laboratory Medicine and Pathology, Director of the Infectious Diseases Serology Laboratory and Associate Director of the Mycology/Mycobacteriology Laboratory in the Division of Clinical Microbiology at Mayo Clinic. Dr. Binnicker will provide an overview of the new interferon gamma release assays to aid in the detection of tuberculosis infection. He will also discuss the global impact of tuberculosis (TB), historic perspective on diagnosis, and the recent development of an in vitro whole blood assay for use in the detection of latent TB infection and active TB disease.

In this presentation, we’ll review an exciting and relatively new technology, known as interferon gamma release assay, which is now available to assist in the diagnosis of tuberculosis. First, we’ll discuss the overall principle of this technology, and then I’ll turn our focus to a specific interferon gamma release assay, QuantiFERON TB Gold In-Tube, which we’ve recently implemented into the Infectious Disease serology laboratory at Mayo Clinic. I’ll review the potential applications of this method, its advantages and limitations in comparison to conventional techniques, and then we’ll go over some keys to accurate test performance that may be helpful to you as your hospital or laboratory is considering using this method.



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