Drugs of Abuse Testing

Benzodiazepine, cont.

September 2009

Now, I had kind of alluded to the fact that benzodiazepine metabolism was complex and here is what I mean. Diazepam, which of course, is a prescription drug is metabolized to nordiazepam, which is also a prescription drug, and nordiazepam is then metabolized to oxazepam, which is also a prescription drug. Now, diazepam also has another pathway, which is metabolized to temazepam, which then again is metabolized to oxazepam. And just when you thought it was simple, both temazepam and oxazepam are glucuronidated and excreted. Now another drug, chlordiazepoxide, also ultimately ends up being metabolized to nordiazepam.

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Benzodiazepine, cont.

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• Benzodiazepine, cont.
• Benzodiazepine, cont.
• Benzodiazepine, cont.
• Benzodiazepine, cont.
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