Drugs of Abuse Testing

Heroin

September 2009

Now heroin in this country is an illicit drug, although it is one of the most potent analgesic medications that’s available today. Heroin, or diacetyl morphine, the first metabolic step is a hydrolysis to form monacetyl morphine. This process is very rapid and it is very, very infrequent that we actually find heroin present, but its unique characteristic metabolite, 6-acetyl-morphine we can detect. 6-acetyl-morphine is then hydrolyzed again to morphine, which, of course, we also can detect in the laboratory and is glucuronidated and then excreted in the urine.

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• Introduction
• Objectives
• Drug Use
• Drug Testing
• Drug Metabolism
• Morphine
• Codeine
• Heroin
• Oxymorphone
• Oxycodone
• Hydromorphone
• Hydrocodone
• Methadone
• Cocaine
• THC
• Amphetamine-Type Stimulants
• Benzodiazepine
• Benzodiazepine, cont.
• Benzodiazepine, cont.
• Benzodiazepine, cont.
• Benzodiazepine, cont.
• Benzodiazepine, cont.
• Interpretation
• Summary
• Questions