Drugs of Abuse Testing

Morphine

September 2009

Now I'm going to quickly go over the metabolism of some of these drugs. First I'm going to start with morphine. Morphine, as you know, is an analgesic. It's metabolized by UGT2b7 and is a phase 2 reaction as its glucuronidated. One of the metabolites, which is morphine-6-glucuronide, is a small percentage about 5% to 15% but is actually an active metabolite. The major metabolite is the morphine-3-glucuronide, which is not inactive and, of course, you can glucuronide both the 3 and the 6 making it a digluconuride metabolite.

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• Introduction
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