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Drugs of Abuse Testing

Ordering the Right Test at the Right Time,
and What Does it Mean?


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Drug Metabolism

Slide 31

September 2009

Now it’s important to be able to interpret drug screens; need to know a little bit about drug metabolism. Basically it’s divided into 2 phases: Phase 1 and Phase 2. Phase I being comprised of oxidation and reduction of the drugs, usually mediated by something like an enzyme of the cytochrome p450 class, but again there are other drugs. The phase 2 reactions are conjugation reactions and can conjugate the drugs with the list of compounds indicated here. Generally, the purpose of the metabolism is to generate compounds that are more soluble and that helps aid in excretion.

Drug Metabolism


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