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Biomarkers of Acute Renal Failure


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Origin of Formed Elements in Urinalysis

Slide 6

August 2009

It is not quite fair to say that creatinine is the only biomarker of acute kidney injury. Urinalysis is a very helpful test for identifying evidence of kidney damage. Ordinarily there are very few formed elements in the urine. However, after acute kidney injury, renal epithelial cells can be shed into the tubular lumen and detected in the urine. Furthermore, these can form renal epithelial cell casts when they gel with Tamm Horsfall protein that is present in everyone’s urine. Other elements in the urinary tract can also form casts, including white blood cells that might indicate infection and red blood cells, which typically indicate glomerular inflammation.

Origin of Formed Elements in Urinalysis


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