Biomarkers of Acute Renal Failure
Towards a Kidney Troponin
August 2009
The biomarker field is fairly well developed in cardiology. Release of enzymes such as AST, CPK, and LDH were identified in the 1950s and 60s. These have been refined to include CPK MB and then troponin over the last several decades. Currently, additional biomarkers are being developed that may better identify subtle ongoing ischemia within the myocardium. In comparison, in nephrology, serum creatinine has remained the only real biomarker for many decades. To be fair, there are promising new biomarkers on the horizon, many of which I will discuss today, so this slide may need to be updated soon. The point remains, however, that we have a long way to go catch up to the cardiologists.
Towards a Kidney Troponin |
Jump to section:
- Introduction
- Acute Kidney Injury
- Common Causes of Acute
- Progression From Pre-renal to Acute Tubular Necrosis
- Towards a Kidney Troponin
- Origin of Formed Elements in Urinalysis
- Urinanalysis: A Traditional Biomarker of AKI
- Hyaline Casts
- Renal Epithelial Cell Cast
- Leukocyte Cast
- RBC Cast
- Pigmented Cast
- Granular Cast
- Other Helpful Indices
- Potential Sources of Urinary Biomarkers
- NGAL as a Biomarker
- Studies Support NGAL as a Biomarker of AKI in the Following Situations
- Mayo Renal Laboratory Urinary NGAL Normals
- Normal Urinary NGAL Levels are Not Dependent on Age, but are Higher in Women than Men
- Ongoing Mayo Clinic Clinical Validation Study
- Ongoing Mayo Clinic Clinical Validation Study: Preliminary Results
- Study
- Other Potential Markers on the Horizon
- Mayo Clinic Goals
- Conclusions
- References
- Questions?
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