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Biomarkers of Acute Renal Failure


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Slide 22

August 2009

Kidney injury molecule 1, or KIM-1, is another promising urinary biomarker of acute kidney injury. Like NGAL, it was identified first in animal models, looking at genes and proteins that were up regulated after injury. Expression of KIM-1 is increased in renal cells 12 to 24 hours after injury. This increased KIM-1 expression is mostly by proximal tubular cells, and since the time course of the increase is a little later than NGAL, both tests may turn out to be complementary. For example, NGAL may be quite useful for early detection of acute kidney injury, while KIM-1 picks up cases a little later at time points when NGAL expression may have peaked and started to go down again.



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