Biomarkers of Acute Renal Failure
Study
August 2009
Kidney injury molecule 1, or KIM-1, is another promising urinary biomarker of acute kidney injury. Like NGAL, it was identified first in animal models, looking at genes and proteins that were up regulated after injury. Expression of KIM-1 is increased in renal cells 12 to 24 hours after injury. This increased KIM-1 expression is mostly by proximal tubular cells, and since the time course of the increase is a little later than NGAL, both tests may turn out to be complementary. For example, NGAL may be quite useful for early detection of acute kidney injury, while KIM-1 picks up cases a little later at time points when NGAL expression may have peaked and started to go down again.
Study |
Jump to section:
- Introduction
- Acute Kidney Injury
- Common Causes of Acute
- Progression From Pre-renal to Acute Tubular Necrosis
- Towards a Kidney Troponin
- Origin of Formed Elements in Urinalysis
- Urinanalysis: A Traditional Biomarker of AKI
- Hyaline Casts
- Renal Epithelial Cell Cast
- Leukocyte Cast
- RBC Cast
- Pigmented Cast
- Granular Cast
- Other Helpful Indices
- Potential Sources of Urinary Biomarkers
- NGAL as a Biomarker
- Studies Support NGAL as a Biomarker of AKI in the Following Situations
- Mayo Renal Laboratory Urinary NGAL Normals
- Normal Urinary NGAL Levels are Not Dependent on Age, but are Higher in Women than Men
- Ongoing Mayo Clinic Clinical Validation Study
- Ongoing Mayo Clinic Clinical Validation Study: Preliminary Results
- Study
- Other Potential Markers on the Horizon
- Mayo Clinic Goals
- Conclusions
- References
- Questions?
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