Biomarkers of Acute Renal Failure

Ongoing Mayo Clinic Clinical Validation Study: Preliminary Results

August 2009

This study is ongoing, and we hope to have the data analyzed soon. However, preliminary results indicate that the presence of renal epithelial cells or granular casts in the urinalysis is still a very specific marker of acute kidney injury. However, urinary NGAL is somewhat more sensitive than this traditional marker. We plan to use the complete data set in order to construct receiver operating curves and develop appropriate cutoff values to differentiate cases of acute kidney injury with maximum sensitivity and specificity.

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Preliminary Results

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Jump to section:

• Introduction
• Acute Kidney Injury
• Common Causes of Acute
• Progression From Pre-renal to Acute Tubular Necrosis
• Towards a Kidney Troponin
• Origin of Formed Elements in Urinalysis
• Urinanalysis: A Traditional Biomarker of AKI
• Hyaline Casts
• Renal Epithelial Cell Cast
• Leukocyte Cast
• RBC Cast
• Pigmented Cast
• Granular Cast
• Other Helpful Indices
• Potential Sources of Urinary Biomarkers
• NGAL as a Biomarker
• Studies Support NGAL as a Biomarker of AKI in the Following Situations
• Mayo Renal Laboratory Urinary NGAL Normals
• Normal Urinary NGAL Levels are Not Dependent on Age, but are Higher in Women than Men
• Ongoing Mayo Clinic Clinical Validation Study
• Ongoing Mayo Clinic Clinical Validation Study: Preliminary Results
• Study
• Other Potential Markers on the Horizon
• Mayo Clinic Goals
• Conclusions
• References
• Questions?