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Biomarkers of Acute Renal Failure


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Ongoing Mayo Clinic Clinical Validation Study

Slide 20

August 2009

We are currently completing a clinical validation study at Mayo Clinic, in order to determine optimal cutoff ranges to differentiate normal and disease. To do this, we are looking at urine samples from patients admitted from our emergency room. We will obtain traditional urinalysis, urinary electrolytes, and urinary NGAL levels. We will then determine clinical outcomes by retrospective review of the medical record. Key outcomes will be acute kidney injury by the AKIN criteria as well as mortality. The AKIN criteria were developed by the Acute Kidney Injury Network, and grade severity of acute kidney injury in stages 1-3 based upon degrees of elevation in creatinine and decreases in urinary output.

Ongoing Clinical Validation Study


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