Biomarkers of Acute Renal Failure

Normal Urinary NGAL Levels are Not Dependent on Age, but are Higher in Women than Men

August 2009

When we looked at this normal value data, we found that urinary levels of NGAL were not dependent on age. Urinary NGAL was, however, higher women than in men. Therefore, we will use gender-specific reference ranges. The reason for this gender difference in baseline urinary NGAL excretion is not currently known.

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Normal NGAL Levels are Not Dependent on Age

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• Introduction
• Acute Kidney Injury
• Common Causes of Acute
• Progression From Pre-renal to Acute Tubular Necrosis
• Towards a Kidney Troponin
• Origin of Formed Elements in Urinalysis
• Urinanalysis: A Traditional Biomarker of AKI
• Hyaline Casts
• Renal Epithelial Cell Cast
• Leukocyte Cast
• RBC Cast
• Pigmented Cast
• Granular Cast
• Other Helpful Indices
• Potential Sources of Urinary Biomarkers
• NGAL as a Biomarker
• Studies Support NGAL as a Biomarker of AKI in the Following Situations
• Mayo Renal Laboratory Urinary NGAL Normals
• Normal Urinary NGAL Levels are Not Dependent on Age, but are Higher in Women than Men
• Ongoing Mayo Clinic Clinical Validation Study
• Ongoing Mayo Clinic Clinical Validation Study: Preliminary Results
• Study
• Other Potential Markers on the Horizon
• Mayo Clinic Goals
• Conclusions
• References
• Questions?