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Biomarkers of Acute Renal Failure



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Studies Support NGAL as a Biomarker of AKI in the Following Situations

Slide 17

August 2009

Over the last several years, many clinical studies have been completed looking at urinary NGAL as a biomarker of acute kidney injury. It appears to be a very rapid and useful predictor of acute kidney injury amongst pediatric patients having cardiac surgery or at risk for contrast-induced kidney damage. A recent study in adults also found that increased urinary NGAL release was a good predictor of subsequent kidney injury in patients admitted from a large emergency room. Unfortunately, NGAL also increases somewhat in the urine of patients with chronic kidney disease. Therefore, it may be that NGAL is a better marker of acute injury in pediatric patients as opposed to adult patients, since chronic kidney disease is more commonly a disease of adults. Already mentioned, NGAL is very stable in urine, which does make it a very convenient analyte for the laboratory.

Studies Support NGAL as a Biomarker of AKI

 


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