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Biomarkers of Acute Renal Failure



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NGAL as a Biomarker

Slide 16

August 2009

Neutrophil gelatinase-associated lipocalin, or NGAL, has been recently identified as a particularly promising potential biomarker of acute kidney injury. This 25-kDa protein was initially described in neutrophils, as its name implies. However, it is also expressed in low amounts in many human tissues, including kidney cells. Importantly, expression of NGAL is induced in injured tissues. This up regulation of NGAL expression is quite rapid, usually within 2 to 4 hours of injury. Fortunately, NGAL is also very stable and easily detected in urine.

NGAL as a Biomarker

 


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