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Biomarkers of Acute Renal Failure


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Pigmented Cast

Slide 12

August 2009

The renal epithelial cells that makeup a renal epithelial cell cast can degrade while they are present free in the tubular lumen. In this case, they can form a pigmented or granulated cast. These are less specific than a true renal epithelial cell cast, since other structures such as red cells or white cells can also degrade and form granular casts. Usually, however, large numbers of pigmented granular casts, so called muddy brown casts, are indicative of ongoing acute tubular necrosis (ATN).

Pigmented Cast


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