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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome


Slide 6

July 2009

The clinical diagnosis of myasthenia gravis is based on characteristic clinical findings and EMG (electromyogram) findings. Clinically, the patients have weakness and fatiguability, and this may be limited to the extraocular muscles and/or bulbar muscles and sometimes it is a generalized disorder that affects all muscle types including limb muscles. The weakness is usually improved by rest or anticholinesterase medication. The characteristic EMG findings consist of a decrement in the compound muscle action potential amplitude during repetitive motor nerve stimulation. Frequently in this disorder, chest CT or MRI may reveal thymic enlargement or a mass, which is usually a thymoma.

MG: Clinical Diagnosis


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