Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome
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July 2009
The clinical diagnosis of myasthenia gravis is based on characteristic clinical findings and EMG (electromyogram) findings. Clinically, the patients have weakness and fatiguability, and this may be limited to the extraocular muscles and/or bulbar muscles and sometimes it is a generalized disorder that affects all muscle types including limb muscles. The weakness is usually improved by rest or anticholinesterase medication. The characteristic EMG findings consist of a decrement in the compound muscle action potential amplitude during repetitive motor nerve stimulation. Frequently in this disorder, chest CT or MRI may reveal thymic enlargement or a mass, which is usually a thymoma.
MG: Clinical Diagnosis |
Jump to section:
- Introduction
- Serological Diagnostic Algorithms
- 'Hot Topic' Points
- What are MG and LES?
- What are MG and LES?
- MG: Clinical Diagnosis
- MG: Neoplastic Accompaniments
- LES: Clinical Diagnosis
- LES: Electromyography (EMG) Findings
- LES: Neoplastic Accompaniments
- Autoantibodies Aiding MG Diagnosis
- Autoantibodies Aiding MG Diagnosis
- Single Assay Detects AChR Modulating and AChR Blocking Antibodies
- Serum AChR Modulating Antibody Values and Interpretation
- Reasons to Discontinue Testing for AChR Blocking Antibody
- Striational Antibodies
- Autoantibodies Detected in MG Patients with Thymoma
- Autoantibodies Aiding the Diagnosis of LES
- Autoantibodies Aiding the Diagnosis of LES
- Myasthenia Gravis: Adult Diagnostic Algorithm
- Myasthenia Gravis: Pediatric Diagnostic Algorithm
- Myasthenia Gravis: Thymoma Diagnostic Algorithm
- Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm
- Summary
- Questions?
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