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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

What are MG and LES?

Slide 4

July 2009

So, first of all, what are myasthenia gravis and Lambert-Eaton syndrome? Let’s briefly review the clinical and electrophysiological features and how these disorders are diagnosed. Both myasthenia gravis and Lambert-Eaton syndrome are autoimmune disorders of neuromuscular transmission. They are caused by antibodies binding to extracellular segments of ion channels in nerve and muscle membranes. The loss of channel protein function in these disorders leads to weakness. Neoplasia or cancer in some cases drives the autoimmune response.

What are MG and LES?


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