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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm

Slide 23

July 2009

For the myasthenia gravis and Lambert-Eaton syndrome diagnostic algorithm, this is generally undertaken where there is some clinical uncertainly as to the diagnosis. Testing always consists of antibodies tests for Lambert-Eaton syndrome consisting of the P/Q-type calcium channel antibody, N-type calcium channel antibody, and then antibody tests pertaining to myasthenia gravis consisting of acetylcholine receptor binding antibody, modulating antibodies, and striational antibody. Again, if the acetylcholine receptor modulating antibodies loss is >90% and the striational antibody is present, testing is automatically reflexed to the ganglionic acetylcholine receptor antibody and CRMP-5-IgG testing.

Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm


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