Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Myasthenia Gravis: Adult Diagnostic Algorithm

July 2009

The diagnostic algorithms that I am now going to describe consist of tests that are always done and then additional testing that is done depending on the initial results. As you will see from these algorithms in this and the following slides, this additional reflex testing is only undertaken where the initial results are suspicious for a diagnosis of thymoma. The additional testing in that setting is to look for other antibodies which would support a diagnosis of thymoma. So, with regard to the myasthenia gravis adult diagnostic algorithm, the testing that is always performed consists of the muscle acetylcholine receptor binding antibody, modulating antibodies, and striated muscle antibodies. If the acetylcholine receptor modulating antibody loss is >90% and striational antibodies are present, then there is reflex testing performed in addition that consists of the ganglionic acetylcholine receptor antibody, GAD65 antibody, the voltage-gated potassium channel autoantibody, and CRMP-5-IgG western blot.

< Previous Slide

Adult Diagnostic Algorithm

Next Slide >

 

Jump to section:

• Introduction
• Serological Diagnostic Algorithms
• 'Hot Topic' Points
• What are MG and LES?
• What are MG and LES?
• MG: Clinical Diagnosis
• MG: Neoplastic Accompaniments
• LES: Clinical Diagnosis
• LES: Electromyography (EMG) Findings
• LES: Neoplastic Accompaniments
• Autoantibodies Aiding MG Diagnosis
• Autoantibodies Aiding MG Diagnosis
• Single Assay Detects AChR Modulating and AChR Blocking Antibodies
• Serum AChR Modulating Antibody Values and Interpretation
• Reasons to Discontinue Testing for AChR Blocking Antibody
• Striational Antibodies
• Autoantibodies Detected in MG Patients with Thymoma
• Autoantibodies Aiding the Diagnosis of LES
• Autoantibodies Aiding the Diagnosis of LES
• Myasthenia Gravis: Adult Diagnostic Algorithm
• Myasthenia Gravis: Pediatric Diagnostic Algorithm
• Myasthenia Gravis: Thymoma Diagnostic Algorithm
• Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm
• Summary
• Questions?