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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Myasthenia Gravis: Adult Diagnostic Algorithm

Slide 20

July 2009

The diagnostic algorithms that I am now going to describe consist of tests that are always done and then additional testing that is done depending on the initial results. As you will see from these algorithms in this and the following slides, this additional reflex testing is only undertaken where the initial results are suspicious for a diagnosis of thymoma. The additional testing in that setting is to look for other antibodies which would support a diagnosis of thymoma. So, with regard to the myasthenia gravis adult diagnostic algorithm, the testing that is always performed consists of the muscle acetylcholine receptor binding antibody, modulating antibodies, and striated muscle antibodies. If the acetylcholine receptor modulating antibody loss is >90% and striational antibodies are present, then there is reflex testing performed in addition that consists of the ganglionic acetylcholine receptor antibody, GAD65 antibody, the voltage-gated potassium channel autoantibody, and CRMP-5-IgG western blot.

Adult Diagnostic Algorithm


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