Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Autoantibodies Detected in MG Patients with Thymoma

July 2009

These and other antibody tests are positive in patients with thymoma, as well as myasthenia gravis. The acetylcholine receptor binding antibody is present in 100% of patients with thymoma. The acetylcholine receptor modulating antibody is present in almost all patients - 99% of patients with thymoma. Striational antibodies are present in 76% of patients with thymoma. And then a variety of other neural-specific antibodies are present in 43% of patients with thymoma. This includes the voltage-gated potassium channel antibody, CRMP-5 IgG, the ganglionic acetylcholine receptor antibody, and GAD65 antibody, which is the commonest neural antibody detected in patients with thymoma.

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MG Patients with Thymoma

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Jump to section:

• Introduction
• Serological Diagnostic Algorithms
• 'Hot Topic' Points
• What are MG and LES?
• What are MG and LES?
• MG: Clinical Diagnosis
• MG: Neoplastic Accompaniments
• LES: Clinical Diagnosis
• LES: Electromyography (EMG) Findings
• LES: Neoplastic Accompaniments
• Autoantibodies Aiding MG Diagnosis
• Autoantibodies Aiding MG Diagnosis
• Single Assay Detects AChR Modulating and AChR Blocking Antibodies
• Serum AChR Modulating Antibody Values and Interpretation
• Reasons to Discontinue Testing for AChR Blocking Antibody
• Striational Antibodies
• Autoantibodies Detected in MG Patients with Thymoma
• Autoantibodies Aiding the Diagnosis of LES
• Autoantibodies Aiding the Diagnosis of LES
• Myasthenia Gravis: Adult Diagnostic Algorithm
• Myasthenia Gravis: Pediatric Diagnostic Algorithm
• Myasthenia Gravis: Thymoma Diagnostic Algorithm
• Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm
• Summary
• Questions?