Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome
Striational Antibodies
July 2009
Another test, when positive, that is supportive of a diagnosis of myasthenia gravis is the striational antibody test. This antibody is detected by an enzyme immunoassay using a mixture of muscle sarcoma proteins as antigen. Seropositivity supports a clinical diagnosis of acquire myasthenia gravis in immunosuppressed patients. Seropositivity supports the diagnosis of thymoma or other neoplasm only when acetylcholine receptor modulating antibody is present and >90% loss is detected. The striational antibody may also be positive in other autoimmune diseases including autoimmune thyroiditis and pernicious anemia.
Striational Antibodies |
Jump to section:
- Introduction
- Serological Diagnostic Algorithms
- 'Hot Topic' Points
- What are MG and LES?
- What are MG and LES?
- MG: Clinical Diagnosis
- MG: Neoplastic Accompaniments
- LES: Clinical Diagnosis
- LES: Electromyography (EMG) Findings
- LES: Neoplastic Accompaniments
- Autoantibodies Aiding MG Diagnosis
- Autoantibodies Aiding MG Diagnosis
- Single Assay Detects AChR Modulating and AChR Blocking Antibodies
- Serum AChR Modulating Antibody Values and Interpretation
- Reasons to Discontinue Testing for AChR Blocking Antibody
- Striational Antibodies
- Autoantibodies Detected in MG Patients with Thymoma
- Autoantibodies Aiding the Diagnosis of LES
- Autoantibodies Aiding the Diagnosis of LES
- Myasthenia Gravis: Adult Diagnostic Algorithm
- Myasthenia Gravis: Pediatric Diagnostic Algorithm
- Myasthenia Gravis: Thymoma Diagnostic Algorithm
- Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm
- Summary
- Questions?
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