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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Striational Antibodies

Slide 16

July 2009

Another test, when positive, that is supportive of a diagnosis of myasthenia gravis is the striational antibody test. This antibody is detected by an enzyme immunoassay using a mixture of muscle sarcoma proteins as antigen. Seropositivity supports a clinical diagnosis of acquire myasthenia gravis in immunosuppressed patients. Seropositivity supports the diagnosis of thymoma or other neoplasm only when acetylcholine receptor modulating antibody is present and >90% loss is detected. The striational antibody may also be positive in other autoimmune diseases including autoimmune thyroiditis and pernicious anemia.

Striational Antibodies


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