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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Serum AChR Modulating Antibody Values and Interpretation

Slide 14

July 2009

Results from the modulating assay should be interpreted as follows: for patients who do not have myasthenia gravis, one can detect 0% to 20% loss of the acetylcholine receptor. Patients with myasthenia gravis, you see >30% loss, and the amount of loss is generally proportional to clinical severity. In patients who have myasthenia gravis with thymoma, the loss of acetylcholine receptor is usually >90%. In patients with Lambert-Eaton syndrome, >30% loss can be encountered in 5% to 10% of patients. All of these antibody values will be lower in immunosuppressed patients.

Antibody Values and Interpretation


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