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Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Single Assay Detects AChR Modulating and AChR Blocking Antibodies

Slide 13

July 2009

Now a single assay detects both modulating and blocking antibodies. Both lower the number of surface binding sites for radiolabeled alpha-bungarotoxin, but do it by 2 different ways. The acetylcholine receptor modulating antibody accelerates endocytosis and degradation of the acetylcholine receptor; whereas, the acetylcholine receptor blocking antibody inhibits alpha-bungarotoxin binding to AChR.

AChR Modulating and Blocking Antibodies


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