Autoantibody Profiles of Myasthenia Gravis, Thymoma & Lambert-Eaton Myasthenic Syndrome

Single Assay Detects AChR Modulating and AChR Blocking Antibodies

July 2009

Now a single assay detects both modulating and blocking antibodies. Both lower the number of surface binding sites for radiolabeled alpha-bungarotoxin, but do it by 2 different ways. The acetylcholine receptor modulating antibody accelerates endocytosis and degradation of the acetylcholine receptor; whereas, the acetylcholine receptor blocking antibody inhibits alpha-bungarotoxin binding to AChR.

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AChR Modulating and Blocking Antibodies

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Jump to section:

• Introduction
• Serological Diagnostic Algorithms
• 'Hot Topic' Points
• What are MG and LES?
• What are MG and LES?
• MG: Clinical Diagnosis
• MG: Neoplastic Accompaniments
• LES: Clinical Diagnosis
• LES: Electromyography (EMG) Findings
• LES: Neoplastic Accompaniments
• Autoantibodies Aiding MG Diagnosis
• Autoantibodies Aiding MG Diagnosis
• Single Assay Detects AChR Modulating and AChR Blocking Antibodies
• Serum AChR Modulating Antibody Values and Interpretation
• Reasons to Discontinue Testing for AChR Blocking Antibody
• Striational Antibodies
• Autoantibodies Detected in MG Patients with Thymoma
• Autoantibodies Aiding the Diagnosis of LES
• Autoantibodies Aiding the Diagnosis of LES
• Myasthenia Gravis: Adult Diagnostic Algorithm
• Myasthenia Gravis: Pediatric Diagnostic Algorithm
• Myasthenia Gravis: Thymoma Diagnostic Algorithm
• Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm
• Summary
• Questions?