Hemoglobin A1c and the Estimated Average Glucose
Fasting Plasma Glucose
July 2009
Disadvantages of using the fasting plasma glucose include that the patient must fast at least 8 hours, and preferably 12 hours; there is a diurnal variation in glucose, such that specimens should be drawn in the morning when values are at their peak and individuals will not be under diagnosed. These two issues both present an inconvenience for the patient. In addition, there is a large biological variability with a fasting glucose, with intraindividual CVs of 5-8% and interindividual CVs of 7-13%. Fasting plasma glucose is also considered to be less sensitive than the oral glucose tolerance test. There are preanalytical problems as well, and it is an often overlooked fact that use of a sodium fluoride collection tube does not prevent glucose degredation for the first 30-90 minutes after the specimen is drawn.
Fasting Plasma Glucose |
Jump to section:
- Introduction
- US Diabetes Prevalence
- Diagnosis of Diabetes
- Categories of Glucose Values
- Importance of Diagnosis
- Role of the Laboratory
- Fasting Plasma Glucose
- Fasting Plasma Glucose
- Hemoglobin A1c (HbA1c)
- Glycation
- HbA1c Concentration
- Diabetes Treatment Goals
- HbA1c Methods
- Hemoglobin Variants
- Hemoglobinopathies
- Reporting HbA1c as an eAG
- HbA1c and Average Glucose
- Derivation of Estimated Average Glucose (eAG)
- HbA1c/eAG Table
- Limitations
- Endorsement of eAG
- HbA1c for Diagnosis of Diabetes
- Disadvantages
- International Expert Committee Report on the Role of the A1c Assay in the Diagnosis of Diabetes
- HbA1c at Mayo Clinic
- Conclusions
- Questions?
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