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Hemoglobin A1c and the Estimated Average Glucose


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Fasting Plasma Glucose

Slide 8

July 2009

Disadvantages of using the fasting plasma glucose include that the patient must fast at least 8 hours, and preferably 12 hours; there is a diurnal variation in glucose, such that specimens should be drawn in the morning when values are at their peak and individuals will not be under diagnosed.  These two issues both present an inconvenience for the patient.  In addition, there is a large biological variability with a fasting glucose, with intraindividual CVs of 5-8% and interindividual CVs of 7-13%.  Fasting plasma glucose is also considered to be less sensitive than the oral glucose tolerance test.  There are preanalytical problems as well, and it is an often overlooked fact that use of a sodium fluoride collection tube does not prevent glucose degredation for the first 30-90 minutes after the specimen is drawn.

Fasting Plasma Glucose


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