Hemoglobin A1c and the Estimated Average Glucose
Disadvantages
July 2009
Some arguments against using HbA1c for diagnosis of diabetes include the limited number of studies which have been performed thus far to derive an adequate cutoff. There are other conditions which alter HbA1c values including the presence of variants, uremia, transfusions, and anemias. Some would also argue there are analytical issues which remain unresolved. HbA1c is also a more expensive analyte to measure in the laboratory than glucose.
Disadvantages |
Jump to section:
- Introduction
- US Diabetes Prevalence
- Diagnosis of Diabetes
- Categories of Glucose Values
- Importance of Diagnosis
- Role of the Laboratory
- Fasting Plasma Glucose
- Fasting Plasma Glucose
- Hemoglobin A1c (HbA1c)
- Glycation
- HbA1c Concentration
- Diabetes Treatment Goals
- HbA1c Methods
- Hemoglobin Variants
- Hemoglobinopathies
- Reporting HbA1c as an eAG
- HbA1c and Average Glucose
- Derivation of Estimated Average Glucose (eAG)
- HbA1c/eAG Table
- Limitations
- Endorsement of eAG
- HbA1c for Diagnosis of Diabetes
- Disadvantages
- International Expert Committee Report on the Role of the A1c Assay in the Diagnosis of Diabetes
- HbA1c at Mayo Clinic
- Conclusions
- Questions?
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