Hemoglobin A1c and the Estimated Average Glucose
HbA1c for Diagnosis of Diabetes
July 2009
In addition to reporting the eAG, hemoglobin A1c has also been targeted for a potential role in the diagnosis of diabetes. The advantages to using HbA1c include that it gives a measurement of chronic hyperglycemia, based on the individuals red blood cell (RBC) lifespan. The standardization efforts from the National Glycohemoglobin Standardization Program have been largely successful and the accuracy of HbA1c is closely monitored by manufacturers and laboratories. No fasting is necessary to measure HbA1c and there is very low intraindividual variability with a CV of <2%. In addition it would be a single test which could be used for both diagnosis and monitoring of diabetes.
HbA1c for Diagnosis of Diabetes |
Jump to section:
- Introduction
- US Diabetes Prevalence
- Diagnosis of Diabetes
- Categories of Glucose Values
- Importance of Diagnosis
- Role of the Laboratory
- Fasting Plasma Glucose
- Fasting Plasma Glucose
- Hemoglobin A1c (HbA1c)
- Glycation
- HbA1c Concentration
- Diabetes Treatment Goals
- HbA1c Methods
- Hemoglobin Variants
- Hemoglobinopathies
- Reporting HbA1c as an eAG
- HbA1c and Average Glucose
- Derivation of Estimated Average Glucose (eAG)
- HbA1c/eAG Table
- Limitations
- Endorsement of eAG
- HbA1c for Diagnosis of Diabetes
- Disadvantages
- International Expert Committee Report on the Role of the A1c Assay in the Diagnosis of Diabetes
- HbA1c at Mayo Clinic
- Conclusions
- Questions?
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