Hemoglobin A1c and the Estimated Average Glucose
Hemoglobinopathies
July 2009
Although there have been over 950 different variants identified, most have a benign phenotype and patients are not affected clinically. However, these variants can cause falsely increased or decreased hemoglobin A1c concentrations and can lead to difficulty in chromatographic interpretation. Boronate affinity methods will give an accurate hemoglobin A1c in these patients, as long as the hemoglobinopathy does not cause issues with red blood cell turnover.
Hemoglobinopathies |
Jump to section:
- Introduction
- US Diabetes Prevalence
- Diagnosis of Diabetes
- Categories of Glucose Values
- Importance of Diagnosis
- Role of the Laboratory
- Fasting Plasma Glucose
- Fasting Plasma Glucose
- Hemoglobin A1c (HbA1c)
- Glycation
- HbA1c Concentration
- Diabetes Treatment Goals
- HbA1c Methods
- Hemoglobin Variants
- Hemoglobinopathies
- Reporting HbA1c as an eAG
- HbA1c and Average Glucose
- Derivation of Estimated Average Glucose (eAG)
- HbA1c/eAG Table
- Limitations
- Endorsement of eAG
- HbA1c for Diagnosis of Diabetes
- Disadvantages
- International Expert Committee Report on the Role of the A1c Assay in the Diagnosis of Diabetes
- HbA1c at Mayo Clinic
- Conclusions
- Questions?
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