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Hemoglobin A1c and the Estimated Average Glucose



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Hemoglobinopathies

Slide 15

July 2009

Although there have been over 950 different variants identified, most have a benign phenotype and patients are not affected clinically.  However, these variants can cause falsely increased or decreased hemoglobin A1c concentrations and can lead to difficulty in chromatographic interpretation.  Boronate affinity methods will give an accurate hemoglobin A1c in these patients, as long as the hemoglobinopathy does not cause issues with red blood cell turnover.

Hemoglobinopathies

 


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