Hemoglobin A1c and the Estimated Average Glucose
HbA1c Concentration
July 2009
Glycation and formation of the stable ketoamine is an irreversible process. The concentration of hemoglobin A1c depends upon several factors. The life span of the red blood cell and how long the hemoglobin A1c is exposed to glucose is a major determining factor. It is also thought that the permeability of the red blood cell to glucose influences the amount of glycation and could explain the discordance noted in some hematologically normal people with diabetes in whom A1c appears discordant from other measures of glycemic control. In general hemoglobin A1c concentrations represent glucose levels over 8-12 weeks. This is precluded in patients who have underlying anemias, hemolysis, B12 or folate deficiencies or hemoglobinopathies which may affect the lifespan of the red blood cells.
HbA1c Concentration |
Jump to section:
- Introduction
- US Diabetes Prevalence
- Diagnosis of Diabetes
- Categories of Glucose Values
- Importance of Diagnosis
- Role of the Laboratory
- Fasting Plasma Glucose
- Fasting Plasma Glucose
- Hemoglobin A1c (HbA1c)
- Glycation
- HbA1c Concentration
- Diabetes Treatment Goals
- HbA1c Methods
- Hemoglobin Variants
- Hemoglobinopathies
- Reporting HbA1c as an eAG
- HbA1c and Average Glucose
- Derivation of Estimated Average Glucose (eAG)
- HbA1c/eAG Table
- Limitations
- Endorsement of eAG
- HbA1c for Diagnosis of Diabetes
- Disadvantages
- International Expert Committee Report on the Role of the A1c Assay in the Diagnosis of Diabetes
- HbA1c at Mayo Clinic
- Conclusions
- Questions?
External
link
PDF
document
Excel
document
Word
document