Hemoglobin A1c and the Estimated Average Glucose
Glycation
July 2009
Hemoglobin glycation occurs when glucose attaches to one or both of the N-terminal valines of the b-chain to form a Schiff’s base. The process is fast and unstable and proceeds to form an irreversible ketoamine through Amadori rearrangement. After a period of weeks, advanced glycation endproducts are formed and broken down.
Glycation |
Jump to section:
- Introduction
- US Diabetes Prevalence
- Diagnosis of Diabetes
- Categories of Glucose Values
- Importance of Diagnosis
- Role of the Laboratory
- Fasting Plasma Glucose
- Fasting Plasma Glucose
- Hemoglobin A1c (HbA1c)
- Glycation
- HbA1c Concentration
- Diabetes Treatment Goals
- HbA1c Methods
- Hemoglobin Variants
- Hemoglobinopathies
- Reporting HbA1c as an eAG
- HbA1c and Average Glucose
- Derivation of Estimated Average Glucose (eAG)
- HbA1c/eAG Table
- Limitations
- Endorsement of eAG
- HbA1c for Diagnosis of Diabetes
- Disadvantages
- International Expert Committee Report on the Role of the A1c Assay in the Diagnosis of Diabetes
- HbA1c at Mayo Clinic
- Conclusions
- Questions?
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