Uses and Limitations of Transcutaneous Bilirubin Measurement

Introduction

June 2009

We know that normal bilirubin levels increase during the first week of newborn life.  Common reasons for this include: Shortened lifespan and increased fragility of the newborn’s RBCs; Immaturity of the liver conjugation system; Increased reabsorption of bilirubin via the enterohepatic circulatory system; and other factors.  Bilirubin at low levels may be an antioxidant and protective but at extreme levels it can cause damage to the brain of the neonate.

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• Introduction
• Outline
• Introduction
• Kernicterus
• Historical Information
• Focus of the Guideline
• Key Elements to the Recommendation
• Key Elements to the Recommendation, cont.
• Mayo Study of TcB
• Mayo Study of TcB, cont.
• Mayo Study of TcB: TcB vs. diazo TsB
• Mayo Study of TcB: TcB vs Vitros TsB
• Mayo Study of TcB
• Mayo Study of TcB, cont.
• Mayo Study of TcB, cont.
• Mayo Study of TcB, cont.
• Conclusions
• Conclusions, cont.
• References
• Questions?