Optimizing Busulfan Pharmacokinetic Testing

Busulfan Patient Information Sheet

June 2009

Each set of samples should be submitted to the lab with a patient information sheet.  In addition to the patient’s name and busulfan dose, it is essential that the lab receives accurate information about the patient’s age, and the weight used to calculate the appropriate dose.  If an adjusted weight is used in calculating busulfan dose, for example, with young children or in overweight patients, the adjusted weight should be provided in the patient information.  Finally, please provide accurate times for the infusion start and stop, and for each of the samples drawn.

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• Introduction
• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?