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Optimizing Busulfan Pharmacokinetic Testing



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Example: A Typical Busulfan Curve, cont.

Slide 5

June 2009

So the patient’s ability to eliminate busulfan is assessed using all four timepoints, as seen with this elimination curve.  In addition, the immediate post infusion sample defines the drug exposure calculated for the two-hour infusion.  In other words, the calculation assumes that the amount of busulfan in the bloodstream throughout the infusion is the same as the concentration measured in the first post-infusion sample.

Example, cont.

 


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