Optimizing Busulfan Pharmacokinetic Testing

Example: A Typical Busulfan Curve, cont.

June 2009

So the patient’s ability to eliminate busulfan is assessed using all four timepoints, as seen with this elimination curve.  In addition, the immediate post infusion sample defines the drug exposure calculated for the two-hour infusion.  In other words, the calculation assumes that the amount of busulfan in the bloodstream throughout the infusion is the same as the concentration measured in the first post-infusion sample.

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Example, cont.

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Jump to section:

• Introduction
• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?