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Optimizing Busulfan Pharmacokinetic Testing



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Example: A Typical Busulfan Curve

Slide 4

June 2009

So what do we see when pharmacokinetic testing is performed?  I’ve shown here a cartoon of typical results for a patient receiving a busulfan infusion.  This is not drawn to scale, but it will serve to illustrate how the AUC is determined.  On this curve, the y-axis is the drug concentration in serum, and the x-axis is the time after stopping the infusion of busulfan.  These are the factors that will determine the AUC, the area under the curve of concentration vs time.  So to calculate the AUC, the first blood sample is taken at the time the busulfan infusion is stopped.  This is called the immediate post-infusion sample, and should contain the highest concentration of busulfan.  Next, to look at elimination of the drug, three more samples are drawn at timepoints of one, two, and four hours after the infusion is stopped.  It is the addition of the initial two hour infusion to the four hour sampling time that makes this the 6 hour AUC.

Example

 


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