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Optimizing Busulfan Pharmacokinetic Testing


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Slide 2

June 2009

Busulfan has been used for decades as an alkylating agent, which means it binds to nucleic acids during cell division, in order to kill the replicating cells.  Busulfan is preferentially toxic to hematopoietic precursor cells, with comparatively little effect on mature lymphocytes, making it a useful agent to ablate bone marrow prior to hematopoietic stem cell transplant.  However, the high doses necessary to successfully prepare bone marrow for stem cell engraftment carry the risk of serious toxicity, including the development of veno-occlusive disease of the liver, or VOD.



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