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Optimizing Busulfan Pharmacokinetic Testing



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The Problem With Atypical Curves

Slide 17

June 2009

As you can see, the effect of having the first two samples switched is considerably different from the effect of diluting the first sample.  The busulfan AUCs are very different for the two scenarios.  Unfortunately, it is generally not possible to discern which of these types of error is the source of a given atypical curve, meaning that the results are uninterpretable.

Problem With Atypical Curves

 


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