Optimizing Busulfan Pharmacokinetic Testing

The Problem With Atypical Curves

June 2009

As you can see, the effect of having the first two samples switched is considerably different from the effect of diluting the first sample.  The busulfan AUCs are very different for the two scenarios.  Unfortunately, it is generally not possible to discern which of these types of error is the source of a given atypical curve, meaning that the results are uninterpretable.

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Problem With Atypical Curves

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Jump to section:

• Introduction
• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?