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Optimizing Busulfan Pharmacokinetic Testing



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Atypical Curve, cont.

Slide 14

June 2009

However, it’s possible that only the first sample is problematic.  We see this commonly with samples drawn from the same intravenous line as was used to administer the busulfan.  What happens is that the saline used to flush the remaining drug from the line gets mixed with the blood drawn in the first sample.  In other words, the post-infusion sample is falsely diluted, and the first concentration should look…

Atypical Curve, cont.

 


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