Optimizing Busulfan Pharmacokinetic Testing

Atypical Curve, cont.

June 2009

However, it’s possible that only the first sample is problematic.  We see this commonly with samples drawn from the same intravenous line as was used to administer the busulfan.  What happens is that the saline used to flush the remaining drug from the line gets mixed with the blood drawn in the first sample.  In other words, the post-infusion sample is falsely diluted, and the first concentration should look…

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Atypical Curve, cont.

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Jump to section:

• Introduction
• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?