Optimizing Busulfan Pharmacokinetic Testing

Atypical Curve

June 2009

Going back to the demonstration cartoon with the normal curve in blue, I’ve added an example of an atypical curve, that’s shown in pink.  As you can see, the first sample does not show the highest concentration of busulfan, which indicates that there is a problem with one or more of the samples.  Because of this, we are unable to determine an accurate AUC.  One question we’re commonly asked is whether we can correct for an atypical curve.  The problem with this sort of correction is that it’s usually not possible to determine…

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Jump to section:

• Introduction
• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?