Optimizing Busulfan Pharmacokinetic Testing

Making Sure You Get Results

June 2009

Completing the patient information sheet properly is the first step in ensuring accurate results for busulfan.  However, I’d like to take this opportunity to highlight the most common problem we see with busulfan testing, and to provide some tips on how to prevent it from happening.  The problem we see most often is referred to as an atypical curve.  What this means is that the first post-infusion sample does not show the highest concentration of busulfan.  I’ll show an example of this visually, then discuss some reasons why it happens.

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Jump to section:

• Introduction
• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?