Optimizing Busulfan Pharmacokinetic Testing

Introduction

June 2009

Welcome to Mayo Medical Laboratories' Hot Topics. These presentations provide short discussion of current topics and may be helpful to you in your practice.

Our speaker for this program is Dr. Christine Snozek, Assistant Professor of Laboratory Medicine and Pathology and Associate Director of the Toxicology and Drug Monitoring Laboratory in the Division of Clinical Biochemistry and Immunology at Mayo Clinic. Dr. Snozek will provide an overview of pharmacokinetic testing for intravenous dosing of busulfan, an alkylating agent used for bone marrow ablation prior to hematopoietic stem cell transplantation. She will discuss the details of specimen collection, assay procedure, and result reporting.

Introduction

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Jump to section:

• Busulfan
• Busulfan Pharmacokinetics
• Example: A Typical Busulfan Curve
• Example: A Typical Busulfan Curve, cont.
• Example: A Typical Busulfan Curve, cont.
• Measuring Drug Exposure
• #83188 Busulfan, Intravenous Dose, Area Under the Curve (AUC), Plasma
• Busulfan Patient Information Sheet
• Making Sure You Get Results
• Atypical Curve
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• Atypical Curve, cont.
• The Problem With Atypical Curves
• Summary
• Questions?