DNA Testing - The Next Generation
High Throughput, High Content Technologies
Complete Workflow
May 2009
So the complete workflow: you see that you start in the original generation, you did 420,000 of these sequences. It’s massive parallelization. The same technology that yields computers with much greater speed by use of massively parallel processing, you are doing the same thing with sequencing. You get sample prep and you get data generation.
Complete Workflow |
Jump to section:
- Introduction
- The Human Genome Project
- ABI 3700 Machine
- Celera Genomics
- Greatest Impact of the Human Genome Project
- Technological Advances
- Process Overview
- One Fragment = One Bead = One Read
- Complete Workflow
- Capability of This Machine
- What's Been Accomplished with the 454?
- Illumina Genome Analyzer
- Genome Analyzer Workflow
- Flow Cell Preparation
- Generate Samples
- Raw Data is Images
- Sequence Construction
- What's Been Accomplished with the Illumina Machine?
- SOLiD System - Overview
- SOLiD System 2.0 - Launch May 2008
- SOLiD System Summary Overview
- Higher Accuracy - New Probe Mix 1,2 Probes (Version 2)
- Higher Accuracy - New Probe Mix 1,2 Probes (Version 2)
- Sequential Rounds of Sequencing 1,2 Probes (Version 2)
- So, What Can You Do with a NextGen Sequencer?
- Whole Genomes
- Detecting Rare Mutations
- Mate-pair Reads
- Hybrid Selection
- Bar Coding
- Clinical Diagnostics
- Next-NextGen?
- Center for Individualized Medicine (CIM)
- Generating a Data Source
- Capabilities Grow Exponentially
- So, What's Coming?
- Building the Infrastructure for NextGen (and Beyond) Sequencing
- Acknowledgments
- Questions?
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