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Thyroid Function Testing: A Brief Update

Appendix The Key Assays-TSH

Slide 18

April 2009

TSH assays are all immunometric. The desirable analytical performance is a functional sensitivity of ≤0.01 mIU/L and all these assays are also known as enhanced third-generation assays. Other useful characteristics are that there is a difference in susceptibility of different TSH assays to either autoantibody interferences or heterophile-antibody interferences. Both of those are not common phenomenon, but they can cause significant headaches in the laboratory and in the clinical practice. Unfortunately, manufacturers don’t exactly advertise that their assay is particularly susceptible, so this type of information travels word-of-mouth amongst laboratorians and clinicians, and if you have any questions, you should consult with your laboratorians and clinicians. Free

Appendix The Key Assays-TSH


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