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Vitamin D Testing

Analytical & Clinical Conundrums


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The Connection Between the Mother and the Infant

Slide 25

January 2009

What is the connection between the mother and the premature infant who had rickets?

This slide will highlight because of the polycystic kidney in the mother, the mother was unable to convert 25-hydroxy vitamin D to 1,25-dihydroxy vitamin D. Lack of 1,25-hydroxy vitamin D prevented mom from absorbing calcium and phosphorus from the diet, even if mom was taking a diet full of calcium.

Low calcium levels during fetus development led to rickets. If the mom was diagnosed with polycystic kidney disease at the appropriate time, the mother should have been treated with 1,25-dihydroxy vitamin D, not the vitamin D that is used for the normal population because in this mom, vitamin D would not be converted to 1,25-dihydroxy vitamin D as the mother lacks one of the hydroxylase to convert 1,25-hydroxy vitamin D. 1,25-hydroxy vitamin D can be obtained in the form of the drug called Calcitriol, which helps in absorbing the calcium and should only be used in rare situations.

Connection Between Mother and Infant


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