Vitamin D Testing

The Connection Between the Mother and the Infant

January 2009

What is the connection between the mother and the premature infant who had rickets?

This slide will highlight because of the polycystic kidney in the mother, the mother was unable to convert 25-hydroxy vitamin D to 1,25-dihydroxy vitamin D. Lack of 1,25-hydroxy vitamin D prevented mom from absorbing calcium and phosphorus from the diet, even if mom was taking a diet full of calcium.

Low calcium levels during fetus development led to rickets. If the mom was diagnosed with polycystic kidney disease at the appropriate time, the mother should have been treated with 1,25-dihydroxy vitamin D, not the vitamin D that is used for the normal population because in this mom, vitamin D would not be converted to 1,25-dihydroxy vitamin D as the mother lacks one of the hydroxylase to convert 1,25-hydroxy vitamin D. 1,25-hydroxy vitamin D can be obtained in the form of the drug called Calcitriol, which helps in absorbing the calcium and should only be used in rare situations.

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Connection Between Mother and Infant

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Jump to section:

• Introduction
• Objectives
• Rickets
• UVB Light
• Vitamin D Deficiency
• Interaction Between Vitamin D and Calcium
• Vitamin D3
• Vitamin D2
• Various Vitamin D Tests
• History of 25-OH Vitamin D Testing
• Accreditation Agencies for Precision Among Peers
• Quality of the 25-OH Vitamin D Testing
• 25-OH Vitamin D Volume
• Reference Ranges for 25-OH Vitamin D
• Various Vitamin D Tests
• Case Study - Rickets in a Premature Infant
• Birth History
• Ionized Calcium
• Fractures Identified on Routine Radiographic Surveillance for Line Placement
• Vitamin D Supplementation
• Lab Values After Vit-D Supplementation
• Mother's History
• Infant's X-ray
• Mother's Creatinine
• The Connection Between the Mother and the Infant
• Summary
• Questions?