Hereditary Hemochromatosis
An Algorithmic Approach to Diagnosis
Laboratory Diagnosis
January 2009
Assuming serum testing and genetic testing have been completed and results are ambiguous, then liver tissue evaluation is indicated. The liver iron test is available. The hepatic iron index is considered diagnostic for hemochromatosis. A hepatic iron index < 1 µmol/year rules out hemochromatosis. A value > 2 µmol/year is diagnostic for hemochromatosis. Surgical pathology consult is also available for tissue histology.
Laboratory Diagnosis |
Jump to section:
- Introduction
- Hereditary Hemochromatosis
- Normal Iron Absorption and Distribution
- Iron Overload Absorption and Distribution
- Iron Uptake, Preservation and Elimination
- Duodenum
- Iron Absorption and Transport by Intestinal Epithelium
- Iron Absorption and Transport by Intestinal Epithelium
- Hemochromatosis-Related Iron Accumulation
- Iron Absorption, Conservation and Transport by Hepatocyte
- Iron Absorption, Conservation and Transport in Hemochromatosis
- Effect of Hemochromatosis on Duodenal Crypt Cell
- Iron Absorption, Conservation and Transport in Hemochromatosis
- Clinical Presentation
- Clinical Presentation
- Hemochromatosis - Clinical Syndrome
- Laboratory Diagnosis: Serum Testing
- HFE Gene
- Hereditary Hemochromatosis
- Inheritance
- Genetic Testing
- Diagnostic Testing Algorithm
- Hemochromatosis - Gross Liver
- Hemochromatosis - Liver Microscopic
- Laboratory Diagnosis
- Treatment
- Summary
- Questions?
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