Hereditary Hemochromatosis
An Algorithmic Approach to Diagnosis
Clinical Presentation
January 2009
The early stages of hemochromatosis are asymptomatic. Frequently, the disease is found by serendipitous evaluation of iron. Hemochromatosis is often suspected when transferrin iron saturation is > 45% and ferritin is > 1000 µg/L. The advanced stage of the disease is indicated when hepatic transaminase concentrations become elevated. Common symptoms of the disease are fatigue, non‑inflammatory osteoarthritis, hypogonadism, diabetes, and skin bronzing.
Clinical Presentation |
Jump to section:
- Introduction
- Hereditary Hemochromatosis
- Normal Iron Absorption and Distribution
- Iron Overload Absorption and Distribution
- Iron Uptake, Preservation and Elimination
- Duodenum
- Iron Absorption and Transport by Intestinal Epithelium
- Iron Absorption and Transport by Intestinal Epithelium
- Hemochromatosis-Related Iron Accumulation
- Iron Absorption, Conservation and Transport by Hepatocyte
- Iron Absorption, Conservation and Transport in Hemochromatosis
- Effect of Hemochromatosis on Duodenal Crypt Cell
- Iron Absorption, Conservation and Transport in Hemochromatosis
- Clinical Presentation
- Clinical Presentation
- Hemochromatosis - Clinical Syndrome
- Laboratory Diagnosis: Serum Testing
- HFE Gene
- Hereditary Hemochromatosis
- Inheritance
- Genetic Testing
- Diagnostic Testing Algorithm
- Hemochromatosis - Gross Liver
- Hemochromatosis - Liver Microscopic
- Laboratory Diagnosis
- Treatment
- Summary
- Questions?
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