Diagnosis and Classification of Amyloidosis
Subtyping
December 2009
To identify the protein causing the amyloidosis, many practices use clinical parameters and surrogate laboratory studies. These may include serum protein electrophoresis, urine protein electrophoresis, immunofixation, assessment of serum free light chain levels, bone marrow examination and mutation analysis for hereditary amyloidosis. However, a monoclonal paraprotein may be absent in AL amyloidosis up to 15% of cases; a monoclonal paraprotein may be present up to 25% of hereditary amyloidosis, and the presence of a germline mutation in an amyloid-associated gene does not necessarily indicate that it is pathogenic. Therefore, tissue- based typing of amyloidosis is essential for disease management.
Subtyping |
Jump to section:
- Introduction
- Amyloidosis
- Diagnosis1
- Slide Images
- Subtypes: Historical Context
- Subtypes2
- Subtyping
- Subtyping
- Subtyping in Tissues
- Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
- Protein Extraction
- Fragmented Peptides
- Mass/charge of Daughter Ions Measured
- Bioinformatics
- Case History 1
- Bone Marrow Biopsy Image
- Flow Cytometry Immunophenotyping
- Bone Marrow Image
- Congo Red-Positive Slide Image
- Immunohistochemistry Slide Images
- Microdissection
- MS-Based Proteomic Analysis
- Diagnosis
- Case History 2
- Mass Spectrometry Results in 50 Cases of Amyloidosis3
- Summary: Diagnosis
- Summary: Classification
- References
- Questions?
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