Diagnosis and Classification of Amyloidosis

Subtyping

December 2009

Given the diversity of proteins that could cause amyloidosis and the clinical syndromes that can be associated with amyloidosis, subtyping of amyloidosis is essential for accurate and effective management. For example AL amyloidosis is treated with high-risk strategies such as peripheral blood stem cell transplantation whereas hereditary ATTR amyloidosis may be treated with liver transplantation.

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Subtyping

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Jump to section:

• Introduction
• Amyloidosis
• Diagnosis¹
• Slide Images
• Subtypes: Historical Context
• Subtypes²
• Subtyping
• Subtyping
• Subtyping in Tissues
• Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
• Protein Extraction
• Fragmented Peptides
• Mass/charge of Daughter Ions Measured
• Bioinformatics
• Case History 1
• Bone Marrow Biopsy Image
• Flow Cytometry Immunophenotyping
• Bone Marrow Image
• Congo Red-Positive Slide Image
• Immunohistochemistry Slide Images
• Microdissection
• MS-Based Proteomic Analysis
• Diagnosis
• Case History 2
• Renal Biopsy Image
• MS-Based Proteomic Analysis
• Diagnosis
• Mass Spectrometry Results in 50 Cases of Amyloidosis³
• Summary: Diagnosis
• Summary: Classification
• References
• Questions?