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Diagnosis and Classification of Amyloidosis



Subtypes2

Slide 6

December 2009

Now we know that at least 25 proteins cause amyloidosis. AL, ATTR and AA-type are the most common amyloidosis and account for approximately 80%-85% of all amyloid cases. However, the remaining 10%-15% is caused by much rarer types. Some of these are systemic in nature and are familial/hereditary. Others are localized, caused by abnormal accumulation of locally produced proteins such as amyloid beta protein, precursor in Alzheimer’s disease, or calcitonin in medullary thyroid cancer.

Subtypes

 


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