Diagnosis and Classification of Amyloidosis
Subtypes2
December 2009
Now we know that at least 25 proteins cause amyloidosis. AL, ATTR and AA-type are the most common amyloidosis and account for approximately 80%-85% of all amyloid cases. However, the remaining 10%-15% is caused by much rarer types. Some of these are systemic in nature and are familial/hereditary. Others are localized, caused by abnormal accumulation of locally produced proteins such as amyloid beta protein, precursor in Alzheimer’s disease, or calcitonin in medullary thyroid cancer.
Subtypes |
Jump to section:
- Introduction
- Amyloidosis
- Diagnosis1
- Slide Images
- Subtypes: Historical Context
- Subtypes2
- Subtyping
- Subtyping
- Subtyping in Tissues
- Mass Spectrometry-Based Proteomic Analysis of Amyloidosis
- Protein Extraction
- Fragmented Peptides
- Mass/charge of Daughter Ions Measured
- Bioinformatics
- Case History 1
- Bone Marrow Biopsy Image
- Flow Cytometry Immunophenotyping
- Bone Marrow Image
- Congo Red-Positive Slide Image
- Immunohistochemistry Slide Images
- Microdissection
- MS-Based Proteomic Analysis
- Diagnosis
- Case History 2
- Mass Spectrometry Results in 50 Cases of Amyloidosis3
- Summary: Diagnosis
- Summary: Classification
- References
- Questions?
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